Résumé
Background: Viral infections such as influenza and COVID-19 pose a serious threat to human health, which increases the demand for a new approach to enhance the host immunity. Previous studies showed that exercise activities could enhance the anti-viral neutralizing antibody titers after vaccination. We developed a novel digital device, SAT-008, as a mobile application based on an algorithm to regulate physical activity which are related to boosting innate and adaptive immune systems against virus. SAT-008 aimed to improve the activity of immune cells and the immune response in the body, which can be induced by software -designed -intensity levels of daily physical activities. Method(s): A randomized, open-label, and controlled study was conducted for 13 weeks (Oct 20 to Jan 21). A total of 42 healthy adults aged 24 to 46 years were recruited for this study and 32 among them served for analysis. Subjects were administered a single-dose quadrivalent influenza vaccine. The control group maintained daily life without using SAT-008, while the experimental group used SAT-008 during the study. Result(s): Compared to the control group, the experimental group showed a significant increase in neutralizing antibody titers of antigen subtype B Yamagata lineage after 4 weeks of vaccination and antigen subtype B Victoria lineage after 12 weeks of vaccination (P < 0.05), whereas the controls did not reach a significant level in any antibody titer. In the case of type 'A' influenza, there was no significant difference in neutralizing antibody titers between control and experimental groups. Stimulated NK cells of subjects in the control group decreased significantly between 4 weeks and 12 weeks after the vaccination (P < 0.05) while the subjects in the experimental group slightly increase the NK activity between 4 weeks and 12 weeks after the vaccination, however, there was no significance. The interaction effect was observed between control and experimental groups at weeks 4 and 12 by subsequent analysis (P < 0.05). Conclusion(s): We conclude that a novel approach using the digital device may play an important role to enhance the host immune system to act as a vaccine adjuvant against viral diseases such as influenza.